The First Plasmodium vivax Relapses of Life Are Usually Genetically Homologous
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منابع مشابه
The First Plasmodium vivax Relapses of Life Are Usually Genetically Homologous
In a prospective infant cohort, 21 infants developed Plasmodium vivax malaria during their first year. Twelve of their mothers also had vivax malaria in the corresponding pregnancies or postpartum period. The genotypes of the maternal and infant infections were all different. Eight of the 12 mothers and 9 of the 21 infants had recurrent infections. Relapse parasite genotypes were different to t...
متن کاملRelapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites.
BACKGROUND Relapses originating from hypnozoites are characteristic of Plasmodium vivax infections. Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection. It has been assumed that parasites causing relapse would be a subset of the parasites that caused the primary infection. METHODS Paired samples were collected before initiation of antimalar...
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متن کاملIdentification of proteins from Plasmodium falciparum that are homologous to reticulocyte binding proteins in Plasmodium vivax.
Plasmodium falciparum infections can be fatal, while P. vivax infections usually are not. A possible factor involved in the greater virulence of P. falciparum is that this parasite grows in red blood cells (RBCs) of all maturities whereas P. vivax is restricted to growth in reticulocytes, which represent only approximately 1% of total RBCs in the periphery. Two proteins, expressed at the apical...
متن کاملPrimaquine for preventing relapses in people with Plasmodium vivax malaria.
BACKGROUND Plasmodium vivax infections contribute to a significant proportion of the malaria infections in many countries. Primaquine is the most widely used drug for treating the dormant liver stage. Different primaquine dosing regimens are in use. OBJECTIVES To compare primaquine regimens for preventing relapses in people with P. vivax malaria. SEARCH STRATEGY In 2006, we searched the Coc...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2011
ISSN: 1537-6613,0022-1899
DOI: 10.1093/infdis/jir806